发明授权
- 专利标题： Selective melanin-concentrating hormone type-1 receptor agonists
- 专利标题（中）： 选择性黑色素浓缩激素1型受体激动剂
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申请号： US10500672申请日： 2003-01-06
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公开(公告)号： US07273846B2公开(公告)日： 2007-09-25
- 发明人: Maria A. Bednarek
- 申请人： Maria A. Bednarek
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Catherine D. Fitch; Sheldon O. Heber
- 国际申请： PCT/US03/00241 WO 20030106
- 国际公布： WO03/060091 WO 20030724
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K38/00
摘要：
The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X6 which is either a D-amino acid, 5-guanidinopropionic acid or its lower or higher homolog, or a derivative thereof; and a X10 which is either asparagine, glutamine, alanine, leucine, isoleucine, valine, norleucine, cyclohexylalanine, phenylalanine, (2′)-naphthylalanine, tyrosine, histidine, tryptophan, lysine, serine, threonine, methionine, or a derivative thereof.
公开/授权文献
- US20050020492A1 Melanin-concentrating hormone analogs 公开/授权日：2005-01-27
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