Methods, systems, and media are disclosed for improved granularity of a response-request communication on a networked computer system. One example embodiment includes receiving the request-response communication by the networked computer system, and associating the request-response communication with a port, having a nodelay setting, from a set of ports on the networked computer system. Further, the example embodiment includes enabling, based upon the associating, the nodelay setting upon connection of the request-response communication with the port. Further still, the example embodiment includes sending, in accordance with the enabling, the request-response communication to a destination in communication with the networked computer system. In addition, further example embodiments include configuring the ports on the networked computer system with nodelay values indicating whether a particular port is assigned nodelay or no nodelay for a request portion or request portion of a request-response communication connecting to that particular port.