发明授权
US07276344B2 Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein
失效
破骨细胞发生抑制因子（OCIF）蛋白的使用方法
- 专利标题： Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein
- 专利标题（中）： 破骨细胞发生抑制因子（OCIF）蛋白的使用方法
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申请号： US10785114申请日： 2004-02-25
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公开(公告)号： US07276344B2公开(公告)日： 2007-10-02
- 发明人: Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
- 申请人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
- 申请人地址： JP Tokyo
- 专利权人： Sankyo Co., Ltd.
- 当前专利权人： Sankyo Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Arnold & Porter LLP
- 优先权： JP7-54977 19950220; JP7-207508 19950721
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K38/00 ; A61K41/00 ; C07K1/00
摘要：
A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis, respectively.The protein can be isolated and purified from culture medium of the said fibroblasts. Furthermore, the protein can be produced by gene engineering.The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity to the protein or a method for determination of the protein concentration using the antibodies.
公开/授权文献
- US20040143859A1 Novel proteins and methods for producing the proteins 公开/授权日：2004-07-22