发明授权
- 专利标题： Cyclic malonamides as inhibitors of Aβ protein protection
- 专利标题（中）： 循环丙二酰胺作为Abeta蛋白质保护的抑制剂
-
申请号： US11327721申请日： 2006-01-06
-
公开(公告)号： US07276496B2公开(公告)日： 2007-10-02
- 发明人: Richard E. Olson , Michael G. Yang
- 申请人： Richard E. Olson , Michael G. Yang
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： US NJ Princeton
- 代理机构： Kelly Drye & Warren LLP
- 代理商 Aldo A. Algieri
- 主分类号： C07D243/24
- IPC分类号： C07D243/24 ; C07D487/00 ; A61K31/55
摘要：
This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
公开/授权文献
信息查询
