发明授权
US07276522B2 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
有权
4-（取代的环烷基甲基）咪唑-2-硫酮，4-（取代的环烯基甲基）咪唑-2-硫酮，4-（取代的环烷基甲基）咪唑-2-酮，4-（取代的环烯基甲基）咪唑-2-酮和相关化合物
- 专利标题： 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
- 专利标题（中）： 4-（取代的环烷基甲基）咪唑-2-硫酮，4-（取代的环烯基甲基）咪唑-2-硫酮，4-（取代的环烷基甲基）咪唑-2-酮，4-（取代的环烯基甲基）咪唑-2-酮和相关化合物
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申请号： US10950376申请日： 2004-09-24
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公开(公告)号： US07276522B2公开(公告)日： 2007-10-02
- 发明人: Todd M. Heidelbaugh , Ken Chow , Phong Nguyen , Daniel Gil , John E. Donello
- 申请人： Todd M. Heidelbaugh , Ken Chow , Phong Nguyen , Daniel Gil , John E. Donello
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理商 Gabor L. Szekeres; Bretn A. Johnson; Martin A. Voet
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D215/00 ; A61K31/4709
摘要：
The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors.
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