发明授权
US07282483B2 Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
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使用具有结合TNF能力的多肽来改善TNF的有害作用的方法
- 专利标题： Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF
- 专利标题（中）： 使用具有结合TNF能力的多肽来改善TNF的有害作用的方法
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申请号： US09898234申请日： 2001-07-03
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公开(公告)号： US07282483B2公开(公告)日： 2007-10-16
- 发明人: Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
- 申请人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 优先权： DEP3913101 19890421; DEP9313101 19890421; DEP3920282 19890621; DEP3920282 19890621; DE90106624 19900406; EP90106624 19900406
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/715
摘要：
The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
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