发明授权
US07285380B2 Methods of producing polyketide synthase mutants and compositions and uses thereof
有权
生产聚酮化合物合酶突变体的方法及其组合物和用途
- 专利标题: Methods of producing polyketide synthase mutants and compositions and uses thereof
- 专利标题(中): 生产聚酮化合物合酶突变体的方法及其组合物和用途
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申请号: US10450230申请日: 2001-12-14
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公开(公告)号: US07285380B2公开(公告)日: 2007-10-23
- 发明人: Joseph P. Noel , Michael B. Austin , Marianne E. Bowman
- 申请人: Joseph P. Noel , Michael B. Austin , Marianne E. Bowman
- 申请人地址: US CA La Jolla
- 专利权人: The Salk Institute for Biological Studies
- 当前专利权人: The Salk Institute for Biological Studies
- 当前专利权人地址: US CA La Jolla
- 代理机构: Foley & Lardner LLP
- 代理商 Stephen E. Reiter
- 国际申请: PCT/US01/48523 WO 20011214
- 国际公布: WO02/057418 WO 20020725
- 主分类号: C12Q1/527
- IPC分类号: C12Q1/527 ; G01N31/00
摘要:
The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.
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