发明授权
US07285563B2 Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain
失效
异环脲衍生物作为治疗疼痛的VR-1受体调节剂
- 专利标题： Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain
- 专利标题（中）： 异环脲衍生物作为治疗疼痛的VR-1受体调节剂
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申请号： US10505358申请日： 2003-03-21
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公开(公告)号： US07285563B2公开(公告)日： 2007-10-23
- 发明人: Rebecca Elizabeth Brown , Victoria Alexandra Doughty , Gregory John Hollingworth , A. Brian Jones , Matthew John Lindon , Christopher Richard Moyes , Lauren Rogers
- 申请人： Rebecca Elizabeth Brown , Victoria Alexandra Doughty , Gregory John Hollingworth , A. Brian Jones , Matthew John Lindon , Christopher Richard Moyes , Lauren Rogers
- 代理商 David Rubin; William Krovatin
- 优先权： GB0206876.5 20020322
- 国际申请： PCT/GB03/01302 WO 20030321
- 国际公布： WO03/080578 WO 20031002
- 主分类号： C07D215/38
- IPC分类号： C07D215/38 ; A61K31/47
摘要：
The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused-carbocyclyl group; as VR-1 antagonists for treating conditions or diseases in which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilizing them
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