发明授权
- 专利标题： Lactams and uses thereof
- 专利标题（中）： 内酰胺及其用途
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申请号： US10528640申请日： 2003-10-02
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公开(公告)号： US07294622B2公开(公告)日： 2007-11-13
- 发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
- 申请人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
- 申请人地址： SE Sodertalje
- 专利权人： Astrazeneca AB
- 当前专利权人： Astrazeneca AB
- 当前专利权人地址： SE Sodertalje
- 代理机构： Pepper Hamilton LLP
- 代理商 Christine McComack
- 优先权： SE0202929 20021003; SE0203829 20021218
- 国际申请： PCT/SE03/01534 WO 20031002
- 国际公布： WO2004/031154 WO 20040415
- 主分类号： C07D223/16
- IPC分类号： C07D223/16 ; C07D267/14 ; C07D281/06 ; A61K31/55 ; A61P25/28
摘要：
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
公开/授权文献
- US20060089346A1 Novel lactams and uses thereof 公开/授权日：2006-04-27
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