发明授权
US07294631B2 Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives
失效
取代的8'-吡啶（MI）二乙基 - 二氢螺环 - [环烷基胺] - 嘧啶并[1,2-a]嘧啶-6-酮衍生物
![Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives](/docs/US/2007-11-13/US07294631B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives
- 专利标题（中）： 取代的8'-吡啶（MI）二乙基 - 二氢螺环 - [环烷基胺] - 嘧啶并[1,2-a]嘧啶-6-酮衍生物
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申请号： US11423557申请日： 2006-06-12
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公开(公告)号： US07294631B2公开(公告)日： 2007-11-13
- 发明人: Nathalie Chereze , Alistair Lochead , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人： Nathalie Chereze , Alistair Lochead , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人地址： FR Paris JP Osaka
- 专利权人： Sanofi-Aventis,Mitsubishi Pharma Corporation
- 当前专利权人： Sanofi-Aventis,Mitsubishi Pharma Corporation
- 当前专利权人地址： FR Paris JP Osaka
- 代理商 Balaram Gupta
- 主分类号： A61K31/527
- IPC分类号： A61K31/527 ; A61K31/551 ; C07D225/08 ; C07D239/20 ; C07D487/20 ; C07D495/10
![Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a]pyrimidin-6-one derivatives](/abs-image/US/2007/11/13/US07294631B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.
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