- 专利标题: Diazabicyclic biaryl derivatives
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申请号: US10513398申请日: 2003-05-06
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公开(公告)号: US07300933B2公开(公告)日: 2007-11-27
- 发明人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
- 申请人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
- 申请人地址: DK Ballerup
- 专利权人: Neurosearch A/S
- 当前专利权人: Neurosearch A/S
- 当前专利权人地址: DK Ballerup
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: DKPA200200692 20020507; DKPA200201739 20021111
- 国际申请: PCT/DK03/00295 WO 20030506
- 国际公布: WO03/094831 WO 20031120
- 主分类号: C07D403/14
- IPC分类号: C07D403/14 ; C07D407/14 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; A61K31/40 ; A61K31/381 ; A61K31/34 ; A61P25/04 ; A61P25/28 ; A61P31/30
摘要:
This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
公开/授权文献
- US20050131236A1 Novel diazabicyclic biaryl derivatives 公开/授权日:2005-06-16