This invention relates to a system and methods for relieving phantomlimb pain in amputees, and for providing an amputee with sensory feedback from a prosthetic limb. The system employs implantable multichannel, multi-chambered interface structures, namely, nerve cuffs. The implanted nerve cuffs have electrodes which transmit electrical signals generated by a signal generator to nerves, recruiting certain neurons to send sensory signals to the cerebral cortex, suggesting sensory sensations to the amputee. Such signals can arise directly from the signal generator, approximating the train of signals seen by the cortex in a normally innervated limb, or can originate from sensors in a prosthetic limb.