A multiplexed computer peripheral device connection switching interface is proposed, which is designed for use with a clustering computer system equipped with a plurality of independent processing units, such as a blade server system equipped with a plurality of server modules; and which is characterized by the capability of allowing a set of peripheral devices (i.e., keyboard and mouse) to be shared by the multiple server modules in a multiplexed manner without having to utilize the more restrictive and lowly compatible USB-to-PS2 converter. This feature allows the multiplexed computer peripheral device connection switching interface of the invention to have a higher cross-platform capability across server platforms with different operating systems.