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发明授权
US07312210B2 Pyrrolo[2,1-c][1,4]benzodiazepine compounds and processes for the preparation thereof 有权
吡咯并[2,1-c] [1,4]苯并二氮杂化合物及其制备方法

Pyrrolo[2,1-c][1,4]benzodiazepine compounds and processes for the preparation thereof
摘要：
The present invention provides novel pyrrolo [2,1-c][1,4]benzodiazepine compounds. This invention also provides a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine compounds. These novel pyrrolo [2,1-c][1,4]benzodiazepine compounds are useful as antitumor agents. It also provides a process for the preparation of 7-methoxy-8-{n-[4-(2-oxo-2H-4-chromenyl)piperazino]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one and 7-methoxy-8-{n-[4-(7-alkoxy-8-methyl-2-oxo-2H-4-chromenyl)piperazino]alkyl}-oxy-(11aS)-1,2,3,11a-5H-pyrrolo[2,1-c][1,4]. benzodiazepine-5-one with aliphatic chain length variations for these compounds.
摘要（中）：

本发明提供新的吡咯并[2,1-c] [1,4]苯并二氮杂化合物。 本发明还提供了制备新型吡咯并[2,1-c] [1,4]苯并二氮杂化合物的方法。 这些新的吡咯并[2,1-c] [1,4]苯并二氮杂化合物可用作抗肿瘤剂。 它还提供了制备7-甲氧基-8- {正 - [4-（2-氧代-2H-4-苯并吡喃基）哌嗪基]烷基} - 氧 - （11aS）-1,2,3,11a -5H-吡咯并[2,1-c] [1,4]苯并二氮杂-5-酮和7-甲氧基-8- {正 - [4-（7-烷氧基-8-甲基-2-氧代-2H- - 烯丙基）哌嗪基]烷基} - 氧基 - （11aS）-1,2,3,11a-5H-吡咯并[2,1-c] [1,4]。 苯并二氮杂-5-酮与这些化合物具有脂肪族链长度变化。

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