发明授权
US07314726B2 Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
有权
β分泌酶外切位点结合肽和用于鉴定β分泌酶调节剂的方法
- 专利标题： Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
- 专利标题（中）： β分泌酶外切位点结合肽和用于鉴定β分泌酶调节剂的方法
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申请号： US10685898申请日： 2003-10-15
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公开(公告)号： US07314726B2公开(公告)日： 2008-01-01
- 发明人: Michael G. Kornacker , Robert A. Copeland , Joseph Hendrick , Zhihong Lai , Claudio Mapelli , Mark Richard Witmer , Jovita Marcinkeviciene , William Metzler , Ving Lee , Douglas James Riexinger
- 申请人： Michael G. Kornacker , Robert A. Copeland , Joseph Hendrick , Zhihong Lai , Claudio Mapelli , Mark Richard Witmer , Jovita Marcinkeviciene , William Metzler , Ving Lee , Douglas James Riexinger
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Melissa Handler; John A. Lamerdin
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
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