发明授权
US07317107B2 Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity
失效
具有腺苷脱氨酶抑制活性的咪唑4-甲酰胺化合物
- 专利标题： Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity
- 专利标题（中）： 具有腺苷脱氨酶抑制活性的咪唑4-甲酰胺化合物
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申请号： US10503585申请日： 2003-02-12
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公开(公告)号： US07317107B2公开(公告)日： 2008-01-08
- 发明人: Kiyoshi Tsuji , Tadashi Terasaka , Nobukiyo Konishi , Takeshi Kato , Katsuya Nakamura
- 申请人： Kiyoshi Tsuji , Tadashi Terasaka , Nobukiyo Konishi , Takeshi Kato , Katsuya Nakamura
- 申请人地址： JP Tokyo
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权： AUPS0581 20020215
- 国际申请： PCT/JP03/01459 WO 20030212
- 国际公布： WO03/068768 WO 20030821
- 主分类号： C07D417/00
- IPC分类号： C07D417/00 ; C07D263/52 ; C07D277/66 ; A61K31/425 ; A61K31/42
摘要：
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective