发明授权
- 专利标题： Chemical synthesis of reagents for peptide coupling
- 专利标题（中）： 肽偶联试剂的化学合成
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申请号： US11229926申请日： 2005-09-19
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公开(公告)号： US07317129B2公开(公告)日： 2008-01-08
- 发明人: Ronald T. Raines , Laura L. Kiessling , Bradley L. Nilsson , Yi He , Matthew B. Soellner , Ronald J. Hinklin
- 申请人： Ronald T. Raines , Laura L. Kiessling , Bradley L. Nilsson , Yi He , Matthew B. Soellner , Ronald J. Hinklin
- 申请人地址： US WI Madison
- 专利权人： Wisconsin Alumni Research Foundation
- 当前专利权人： Wisconsin Alumni Research Foundation
- 当前专利权人地址： US WI Madison
- 代理机构： Greenlee, Winner and Sullivan, P.C.
- 主分类号： C07F5/02
- IPC分类号： C07F5/02
摘要：
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
公开/授权文献
- US20060025578A1 Chemical synthesis of reagents for peptide coupling 公开/授权日：2006-02-02
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