发明授权
- 专利标题： Methods and compositions for identifying receptor effectors
- 专利标题（中）： 用于鉴定受体效应物的方法和组合物
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申请号： US10277607申请日： 2002-10-22
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公开(公告)号： US07319009B2公开(公告)日： 2008-01-15
- 发明人: Christine A. Klein , Andrew J. Murphy , Jeremy Paul
- 申请人： Christine A. Klein , Andrew J. Murphy , Jeremy Paul
- 申请人地址： US NY New York
- 专利权人： Cadus Technologies, Inc.
- 当前专利权人： Cadus Technologies, Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Peter C. Lauro, Esq.; Melissa Hunter Endsor
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; G01N33/554 ; G01N33/566
摘要：
The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.
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