发明授权
US07319033B2 Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
失效
特异于表达雄激素受体的细胞的腺病毒载体及其使用方法
- 专利标题: Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
- 专利标题(中): 特异于表达雄激素受体的细胞的腺病毒载体及其使用方法
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申请号: US10222479申请日: 2002-08-16
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公开(公告)号: US07319033B2公开(公告)日: 2008-01-15
- 发明人: Daniel R. Henderson , Eric R. Schuur , De-Chao Yu
- 申请人: Daniel R. Henderson , Eric R. Schuur , De-Chao Yu
- 申请人地址: US CA South San Francisco
- 专利权人: Cell Genesys, Inc.
- 当前专利权人: Cell Genesys, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: Ropes & Gray, LLP
- 主分类号: C12N15/861
- IPC分类号: C12N15/861 ; C12N15/63 ; C12N15/64 ; A61K48/00
摘要:
Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise an adenoviral gene under control of a transcriptional regulatory portion of a PB-TRE, which is in turn dependent upon AR expression. The gene can be, for example, a gene required for viral replication or the adenovirus death protein gene (ADP). The viruses can also comprise at least one additional adenoviral gene under control of at least one additional prostate-specific transcriptional response element, such as that controlling prostate-specific antigen expression (PSA-TRE). Thus, virus replication can be restricted to target cells exhibiting prostate-specific gene expression, particularly prostate carcinoma cells.