- 专利标题: N-[(piperazinyl)hetaryl]arylsulfonamide compounds
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申请号: US10823317申请日: 2004-04-13
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公开(公告)号: US07320979B2公开(公告)日: 2008-01-22
- 发明人: Wilfried M. Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Hervé Geneste , Liliane Unger , Daryl R. Sauer , Sean C. Turner
- 申请人: Wilfried M. Braje , Andreas Haupt , Wilfried Lubisch , Roland Grandel , Karla Drescher , Hervé Geneste , Liliane Unger , Daryl R. Sauer , Sean C. Turner
- 申请人地址: DE Wiesbaden
- 专利权人: Abbott GmbH & Co. KG.
- 当前专利权人: Abbott GmbH & Co. KG.
- 当前专利权人地址: DE Wiesbaden
- 代理机构: Wood Phillips et al.
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; A61K31/506 ; C07D213/72 ; C07D213/74 ; C07D239/48
摘要:
The invention relates to N-[(piperazinyl)hetaryl]arylsulfonamide compounds of the general formula I in which Q is a bivalent, 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Ra which is/are selected, independently of each other, from halogen, CN, NO2, CO2R4, COR5, C1-C4-alkyl and C1-C4-haloalkyl; Ar is phenyl or a 6-membered heteroaromatic radical which possesses 1 or 2 N atoms as ring members and which optionally carries one or two substituents Rb, which is/are selected from halogen, NO2, CN, CO2R4, COR5, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl and C1-C4-haloalkyl, with it also being possible for two radicals Rb which are bonded to adjacent C atoms of Ar to be together C3-C4-alkylene; R1 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C4-alkenyl or C3-C4-alkynyl; with the radicals n, R1, R2, R3, R4 and R5 having the meanings given in the patent claims, to the N-oxides and to the physiologically tolerated acid addition salts of these compounds and to pharmaceutical compositions which comprise at least one N-[(piperazinyl)hetaryl]arylsulfonamide compound as claimed in one of claims 1 to 10 and/or at least one physiologically tolerated acid addition salt of I and/or an N-oxide of I, where appropriate together with physiologically acceptable carriers and/or auxiliary substances for treating diseases which respond to influencing by dopamine D3 receptor antagonists or agonists, in particular for treating diseases of the central nervous system and disturbances of kidney function.
公开/授权文献
- US20060160809A1 N-[(piperazinyl)hetaryl]arylsulfonamide compounds 公开/授权日:2006-07-20
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