- 专利标题： Prodrug compounds with isoleucine
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申请号： US11540466申请日： 2006-09-29
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公开(公告)号： US07329507B2公开(公告)日： 2008-02-12
- 发明人: Lesley B. Pickford , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Geoffrey T. Yarranton
- 申请人： Lesley B. Pickford , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Geoffrey T. Yarranton
- 申请人地址： US NJ Princeton
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： US NJ Princeton
- 代理机构： Lahive & Cockfield, LLP
- 代理商 Jane E. Remillard, Esq.; Cynthia M. Soroos, Esq.
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; C07K5/08 ; C07K5/10
摘要：
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed.
公开/授权文献
- US20070020694A1 Prodrug compounds with isoleucine 公开/授权日：2007-01-25
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