发明授权
- 专利标题: Anthranilamides and methods of their use
- 专利标题(中): 邻氨基苯甲酰胺及其使用方法
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申请号: US11558132申请日: 2006-11-09
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公开(公告)号: US07332608B2公开(公告)日: 2008-02-19
- 发明人: Joachim Brendel , Stefan Peukert , Heinz-Werner Kleemann , Horst Hemmerle
- 申请人: Joachim Brendel , Stefan Peukert , Heinz-Werner Kleemann , Horst Hemmerle
- 申请人地址: DE Frankurt am Main
- 专利权人: SANOFI-AVENTIS Deutschland GmbH
- 当前专利权人: SANOFI-AVENTIS Deutschland GmbH
- 当前专利权人地址: DE Frankurt am Main
- 代理商 Ronald G. Ort
- 优先权: DE10121003 20010428
- 主分类号: C07D213/02
- IPC分类号: C07D213/02 ; C07C311/04
摘要:
The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).
公开/授权文献
- US20070117807A1 ANTHRANILAMIDES AND METHODS OF THEIR USE 公开/授权日:2007-05-24