Invention Grant
US07351703B2 Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators
有权
磺酰氨基羧酸N-芳基酰胺作为鸟苷酸环化酶活化剂
- Patent Title: Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators
- Patent Title (中): 磺酰氨基羧酸N-芳基酰胺作为鸟苷酸环化酶活化剂
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Application No.: US10957980Application Date: 2004-10-05
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Publication No.: US07351703B2Publication Date: 2008-04-01
- Inventor: Ursula Schindler , Karl Schoenafinger , Hartmut Strobel
- Applicant: Ursula Schindler , Karl Schoenafinger , Hartmut Strobel
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A01N41/06 ; A01N37/12 ; A01N37/44 ; A61K31/55 ; A61K31/54 ; A61K31/535 ; A61K31/4965 ; A61K31/18 ; A61K31/195

Abstract:
The present invention relates to compounds of the formula I in which A1, A2, R2 and R3 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention relates to the use of compounds of the formula I for the therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, novel compounds of the formula I, pharmaceutical preparations comprising them and processes for their preparation.
Public/Granted literature
- US20050080073A1 Sulfonylaminocarboxiylic acid N-arylamides as guanylate cyclase activators Public/Granted day:2005-04-14
Information query
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