A programmable gain amplifier includes a first gain setting circuit and a second gain setting circuit that are both coupled to an output of an amplifier. A trim adjustment circuit is and arranged to complete feedback to the amplifier by digitally panning between the first gain setting and the second gain setting based on a trim setting. The trim setting can be provided by a look-up table that is indexed with gain settings. The first and the second gain setting circuits can each include an array of series coupled resistors, where a tap point from each array is selectively coupled to the trim adjustment circuit for adjusting the overall gain. The first and second gain setting circuits can be matched to one another, with the addition of a gain offset circuit that is configured to skew the nominal gain values between the first and second gain setting circuits.