Invention Grant
- Patent Title: Thiazolidinedione derivative and its use as antidiabetic
- Patent Title (中): 噻唑烷二酮衍生物及其用作抗糖尿病药
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Application No.: US11458471Application Date: 2006-07-19
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Publication No.: US07358366B2Publication Date: 2008-04-15
- Inventor: Paul David James Blackler , Robert Gordon Giles , Stephen Moore , Michael John Sasse
- Applicant: Paul David James Blackler , Robert Gordon Giles , Stephen Moore , Michael John Sasse
- Applicant Address: GB Brentford, Middlesex
- Assignee: SmithKline Beecham p.l.c.
- Current Assignee: SmithKline Beecham p.l.c.
- Current Assignee Address: GB Brentford, Middlesex
- Agent Kathryn L. Sieburth; Mary E. McCarthy; Charles M. Kinzig
- Priority: GB9909471.6 19990423; GB9912195.6 19990525
- Main IPC: C07D417/12
- IPC: C07D417/12

Abstract:
A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm−1; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm−1; and/or (iii) a solid-state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0, and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
Public/Granted literature
- US20060247279A1 THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC Public/Granted day:2006-11-02
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