发明授权
- 专利标题： Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril
- 专利标题（中）： 制备7-（4-溴丁氧基）-3,4-二氢喹诺酮的方法
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申请号： US11053072申请日： 2005-02-07
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公开(公告)号： US07361756B2公开(公告)日： 2008-04-22
- 发明人: Ben-Zion Dolitzky , Jean Hildesheim , Alisa Berlin
- 申请人： Ben-Zion Dolitzky , Jean Hildesheim , Alisa Berlin
- 申请人地址： IL Petah Tiqva
- 专利权人： Teva Pharmaceutical Industries Ltd.
- 当前专利权人： Teva Pharmaceutical Industries Ltd.
- 当前专利权人地址： IL Petah Tiqva
- 代理机构： Kenyon & Kenyon LLP
- 主分类号： C07D265/00
- IPC分类号： C07D265/00 ; C07D215/38
摘要：
The invention encompasses synthesizing 7-(4-bromobutoxy)-3,4-dihydrocarbostyril by mixing 7-hydroxy-tetrahydroquinolinone, dibromobutane, and at least one base to form a reaction mixture; heating the reaction mixture; cooling the reaction mixture; and isolating the 7-(4-bromobutoxy)-3,4-dihydrocarbostyril from the reaction mixture. The invention also encompasses using phase transfer catalysts during the reaction.