A system may include a plurality of nodes. Each node may include one or more active devices coupled to one or more memory subsystems. Each active device in one of the plurality of nodes includes a memory management unit configured to receive a virtual address generated within that active device and to responsively output a global address and associated information that identifies a translation function. The memory subsystem in the one of the plurality of nodes is configured to apply the translation function identified in the information to the global address to generate a local physical address.