Partial oxidation process of liquid fuels, selected from hydrocarbon and/or oxygenated compounds, together with gaseous fuels, selected from hydrocarbon compounds, natural gas and LPG, by means of a suitable catalytic system comprising the following steps: premixing the reagents and possibly heating them to temperatures ranging from 25 to 400° C., said reagents consisting of said liquid fuels, said gaseous fuels and oxygen or air or oxygen enriched air, optionally in the presence of vapor and/or CO2; reacting the mixture of reagents in the catalytic zone, at inlet temperatures ranging from 50 to 500° C. and space velocities ranging from 1,000 to 1,000,000 Nl reagents/L cat×h, reaching temperatures ranging from 450 to 1350° C.