发明授权
US07371767B2 Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
失效
代谢型谷氨酸受体-5的杂芳基取代吡咯调节剂
- 专利标题： Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
- 专利标题（中）： 代谢型谷氨酸受体-5的杂芳基取代吡咯调节剂
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申请号： US10499393申请日： 2002-12-17
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公开(公告)号： US07371767B2公开(公告)日： 2008-05-13
- 发明人: Nicholas D. P. Cosford , Dehua Huang , Nicholas D. Smith
- 申请人： Nicholas D. P. Cosford , Dehua Huang , Nicholas D. Smith
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 J. Eric Thies; William Krovatin
- 国际申请： PCT/US02/40486 WO 20021217
- 国际公布： WO03/059904 WO 20030724
- 主分类号： A61K31/4433
- IPC分类号： A61K31/4433 ; A61K31/427 ; C07D277/32 ; C07D231/14 ; C07D207/325
摘要：
Pyrrole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorder and panic, as well as in the treatment of pain, circadian rhythm disorders, and other diseases.
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