发明授权
- 专利标题： Spiro and dispiro 1,2,4-trioxolane antimalarials
- 专利标题（中）： 螺和脱甲基-1,2,4-三恶烷抗疟药
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申请号： US11121451申请日： 2005-05-04
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公开(公告)号： US07371778B2公开(公告)日： 2008-05-13
- 发明人: Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Xiaofang Wang , Kamaraj Spiraghavan , William N. Chapman
- 申请人： Jonathan L. Vennerstrom , Yuxiang Dong , Jacques Chollet , Hugues Matile , Xiaofang Wang , Kamaraj Spiraghavan , William N. Chapman
- 申请人地址： CH
- 专利权人： Medicines for Malaria Venture MMV
- 当前专利权人： Medicines for Malaria Venture MMV
- 当前专利权人地址： CH
- 代理机构： McKee, Voorhees & Sease, P.L.C.
- 主分类号： A61K31/357
- IPC分类号： A61K31/357 ; C07D323/02
摘要：
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
公开/授权文献
- US20050256185A1 Spiro and dispiro 1,2,4-trioxolane antimalarials 公开/授权日：2005-11-17
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