Invention Grant
US07381522B2 Non-endogenous, constitutively activated known G protein-coupled receptors
失效
非内源性，组成型激活的已知G蛋白偶联受体
- Patent Title: Non-endogenous, constitutively activated known G protein-coupled receptors
- Patent Title (中): 非内源性，组成型激活的已知G蛋白偶联受体
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Application No.: US11404939Application Date: 2006-04-14
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Publication No.: US07381522B2Publication Date: 2008-06-03
- Inventor: Karin Lehmann-Bruinsma , Chen W. Liaw , I-Lin Lin
- Applicant: Karin Lehmann-Bruinsma , Chen W. Liaw , I-Lin Lin
- Applicant Address: US CA San Diego
- Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Bozicevic, Field & Francis LLP
- Agent David C. Scherer; Carol L. Francis
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; G01N33/53 ; G01N33/566
Abstract:
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.
Public/Granted literature
- US20060183164A1 Non-endogenous, constitutively activated known G protein-coupled receptors Public/Granted day:2006-08-17
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