Invention Grant
US07384941B2 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
失效
2-（苯氧基甲基） - 和2-（苯硫基甲基） - 吗啉衍生物，用作选择性去甲肾上腺素再摄取抑制剂
- Patent Title: 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors
- Patent Title (中): 2-（苯氧基甲基） - 和2-（苯硫基甲基） - 吗啉衍生物，用作选择性去甲肾上腺素再摄取抑制剂
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Application No.: US10524650Application Date: 2003-08-18
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Publication No.: US07384941B2Publication Date: 2008-06-10
- Inventor: Magnus Wilhelm Walter , Barry Peter Clark , Peter Thaddeus Gallagher , Helen Louise Haughton , Hélène Catherine Eugénie Rudyk
- Applicant: Magnus Wilhelm Walter , Barry Peter Clark , Peter Thaddeus Gallagher , Helen Louise Haughton , Hélène Catherine Eugénie Rudyk
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Charles E. Cohen; Tonya L. Combs; Thomas E. Jackson
- Priority: GB0219690.5 20020823
- International Application: PCT/US03/23269 WO 20030818
- International Announcement: WO2004/017977 WO 20040304
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D265/30
Abstract:
Compounds of formula (I): wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3-C6 cycloalkyl group or a CH2(C3-C6 cycloalkyl) group; R′ is H or C1-C4 alkyl; and each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof are selective inhibitors of norepinephrine reuptake.
Public/Granted literature
- US20060035894A1 Morpholine derivatives Public/Granted day:2006-02-16
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