Spread spectrum receiver architectures and methods are described for reducing interference, particularly the interference observed at a user-end terminal in a W-CDMA 3G mobile communications system. Interpath interference which arises due to non-zero cross and auto correlation of more than one spreading code is suppressed by estimating a transmitted signal stream, or a plurality of such signal streams in the case of a plurality of multipath components, respreading this estimated signal and subtracting non-orthogonal interference contributions from a received signal. The techniques provide an improved bit error rate or equivalently, enhanced capacity for a digital mobile communications network.