发明授权
- 专利标题： Prodrugs of phosphonate nucleotide analogues
- 专利标题（中）： 膦酸酯核苷酸类似物的前药
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申请号： US10798692申请日： 2004-03-11
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公开(公告)号： US07390791B2公开(公告)日： 2008-06-24
- 发明人: Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
- 申请人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
- 申请人地址： US CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Foster City
- 代理商 Max D. Hensley
- 主分类号： A01N43/48
- IPC分类号： A01N43/48 ; A61K3/1675 ; C07F9/6512
摘要：
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
公开/授权文献
- US20050009043A1 Prodrugs of phosphonate nucleotide analogues 公开/授权日：2005-01-13
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