发明授权
US07393853B2 Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives as therapeutic agents
失效
取代的8-全氟烷基-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮衍生物作为治疗剂
![Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives as therapeutic agents](/docs/US/2008-07-01/US07393853B2/abs.jpg.600x600.jpg)
- 专利标题： Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives as therapeutic agents
- 专利标题（中）： 取代的8-全氟烷基-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮衍生物作为治疗剂
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申请号： US11696256申请日： 2007-04-04
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公开(公告)号： US07393853B2公开(公告)日： 2008-07-01
- 发明人: Alistair Lochead , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人： Alistair Lochead , Mourad Saady , Franck Slowinski , Philippe Yaiche
- 申请人地址： FR Paris JP Osaka
- 专利权人： Sanofi Aventis,Mitsubishi Pharma Corp.
- 当前专利权人： Sanofi Aventis,Mitsubishi Pharma Corp.
- 当前专利权人地址： FR Paris JP Osaka
- 代理商 Balaram Gupta
- 优先权： EP03290728 20030321
- 主分类号： A61K31/519
- IPC分类号： A61K31/519
![Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives as therapeutic agents](/abs-image/US/2008/07/01/US07393853B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3β, such as Pick's disease.