A workpiece holding system (10) is configured for holding a workpiece (R) for crafting thereof by a craftsman (C). The system (10) broadly includes a mounting assembly (12) removably coupled a support surface (B), an articulating frame assembly (14) coupled to the mounting assembly (12), a workpiece-supporting tool assembly (16) removably coupled to the frame assembly (14), and a mirrored ambidextrous handrest assembly (18) removably coupled to the mounting assembly (12). A fixture (36) spaced from a work zone (W) adjustably receives the tool assembly (16) so that the workpiece (R) held therein can be positioned substantially in the work zone (W) so that when the tool assembly (16) is maneuvered, thereby articulating the frame assembly (14), the workpiece (R) substantially remains in the work zone (W). The tool assembly (16) includes a connection assembly (80) configured to quickly and removably couple tools (78, 140, 152, 154, 172) into a clamp (76).