发明授权
US07399827B1 Page-4, an x-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor
失效
第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的x连接的量规样基因，并用于其
- 专利标题： Page-4, an x-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor
- 专利标题（中）： 第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的x连接的量规样基因，并用于其
-
申请号： US09763393申请日： 1999-08-31
-
公开(公告)号： US07399827B1公开(公告)日： 2008-07-15
- 发明人: Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
- 申请人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 国际申请： PCT/US99/20046 WO 19990831
- 国际公布： WO00/12706 WO 20000309
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
信息查询
