发明授权
- 专利标题： In vivo activation of tumor-specific cytotoxic T cells
- 专利标题（中）： 肿瘤特异性细胞毒性T细胞的体内活化
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申请号： US09277064申请日： 1999-03-26
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公开(公告)号： US07402314B2公开(公告)日： 2008-07-22
- 发明人: Linda A. Sherman
- 申请人： Linda A. Sherman
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 代理商 Hugh Wang; Thomas Fitting; Michael J. McCarthy
- 主分类号： A61K39/00
- IPC分类号： A61K39/00
摘要：
The present invention relates to methods and compositions of activating cytotoxic T lymphocytes (CTLs) in vivo with specificity for particular antigenic peptides, and to methods and compositions of using activated CTLs in vivo for the treatment of a variety of disease conditions. In some preferred embodiments, the invention provides methods of employing a polypeptide of the amino acid sequence VMAGVGSPYV to specifically activating CTLs in subjects having a breast cancer overexpressing a Her-2/Neu protein, and methods of using the polypeptide to treat such subjects.
公开/授权文献
- US20030064916A1 IN VIVO ACTIVATION OF TUMOR-SPECIFIC CYTOTOXIC T CELLS 公开/授权日：2003-04-03
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