发明授权
US07405272B2 Selectin ligand interactor cytoplasmic (SLIC-1), a P-selectin glycoprotein ligand (PSGL-1) binding protein
失效
选择素配体相互作用细胞质（SLIC-1），P-选择素糖蛋白配体（PSGL-1）结合蛋白
- 专利标题： Selectin ligand interactor cytoplasmic (SLIC-1), a P-selectin glycoprotein ligand (PSGL-1) binding protein
- 专利标题（中）： 选择素配体相互作用细胞质（SLIC-1），P-选择素糖蛋白配体（PSGL-1）结合蛋白
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申请号： US10961070申请日： 2004-10-12
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公开(公告)号： US07405272B2公开(公告)日： 2008-07-29
- 发明人: Meike Lorenz , Ron Kriz , Nadine Weich , Gray D. Shaw
- 申请人： Meike Lorenz , Ron Kriz , Nadine Weich , Gray D. Shaw
- 申请人地址： US MA Cambridge
- 专利权人： Genetics Institute, L.L.C.
- 当前专利权人： Genetics Institute, L.L.C.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 主分类号： C07K14/705
- IPC分类号： C07K14/705
摘要：
The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.