发明授权
- 专利标题: Therapeutic and diagnostic conjugates for use with multispecific antibodies
- 专利标题(中): 用于多特异性抗体的治疗和诊断缀合物
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申请号: US10776470申请日: 2004-02-11
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公开(公告)号: US07405320B2公开(公告)日: 2008-07-29
- 发明人: William J. McBride , David M. Goldenberg , Carl Noren , Hans J. Hansen
- 申请人: William J. McBride , David M. Goldenberg , Carl Noren , Hans J. Hansen
- 申请人地址: US NJ Morris Plains
- 专利权人: Immunomedics, Inc.
- 当前专利权人: Immunomedics, Inc.
- 当前专利权人地址: US NJ Morris Plains
- 代理商 Richard A. Nakashima
- 主分类号: C07C229/00
- IPC分类号: C07C229/00 ; A61K39/00 ; C07K1/00
摘要:
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
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