Invention Grant
- Patent Title: N-aryl pyrrolidine derivatives as beta-secretase inhibitors
- Patent Title (中): N-芳基吡咯烷衍生物作为β-分泌酶抑制剂
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Application No.: US11693034Application Date: 2007-03-29
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Publication No.: US07408071B2Publication Date: 2008-08-05
- Inventor: Kenneth M. Boy , Shirong Zhu , John E. Macor , Shuhao Shi , Samuel Gerritz
- Applicant: Kenneth M. Boy , Shirong Zhu , John E. Macor , Shuhao Shi , Samuel Gerritz
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Aldo A. Algieri
- Main IPC: C07D207/04
- IPC: C07D207/04 ; C07D207/00 ; A01N43/64 ; A01N43/36

Abstract:
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
Public/Granted literature
- US20070232679A1 N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors Public/Granted day:2007-10-04
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