A folding chair with wheels includes a backrest, a seat, a front leg frame and a rear leg frame pivotally connected to both sides of the seat, a plurality of wheel assemblies and a plurality of connection blocks. Each of the front leg frame and the rear leg frame comprises a groove at a side surface thereof. The wheel assembly includes a wheel, a bearing and a threaded stem screwed into the connection block. The connection block has a plurality of connection screw holes, and is screwed onto the grooves of the front leg frame and the rear leg frame by bolts. The wheel assemblies connected with the front leg frame and the rear leg frame are disposed at the external side and the internal side of the folding chair, respectively. Therefore, the wheel assemblies do not interfere with each other when the chair is folded.