发明授权
US07417110B2 Biodegradable polyphosphoramidates for controlled release of bioactive substances
失效
用于生物活性物质控制释放的可生物降解的聚磷酸酰胺酯
- 专利标题: Biodegradable polyphosphoramidates for controlled release of bioactive substances
- 专利标题(中): 用于生物活性物质控制释放的可生物降解的聚磷酸酰胺酯
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申请号: US10500565申请日: 2002-05-14
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公开(公告)号: US07417110B2公开(公告)日: 2008-08-26
- 发明人: Jun Wang , Hai-Quan Mao , Kam Weng Leong
- 申请人: Jun Wang , Hai-Quan Mao , Kam Weng Leong
- 代理机构: Greenberg Traurig
- 国际申请: PCT/SG02/00091 WO 20020514
- 国际公布: WO03/000776 WO 20030103
- 主分类号: C08G79/02
- IPC分类号: C08G79/02 ; C08G79/04 ; C08J3/07
摘要:
The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.