发明授权
US07419983B2 Gonadotropin-releasing hormone receptor antagonists and methods related thereto
有权
促性腺激素释放激素受体拮抗剂及其相关方法
- 专利标题: Gonadotropin-releasing hormone receptor antagonists and methods related thereto
- 专利标题(中): 促性腺激素释放激素受体拮抗剂及其相关方法
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申请号: US11627204申请日: 2007-01-25
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公开(公告)号: US07419983B2公开(公告)日: 2008-09-02
- 发明人: Zhiqiang Guo , Yongsheng Chen , Dongpei Wu , Chen Chen , Warren Wade , Wesley J. Dwight , Charles Q. Huang , Fabio C. Tucci
- 申请人: Zhiqiang Guo , Yongsheng Chen , Dongpei Wu , Chen Chen , Warren Wade , Wesley J. Dwight , Charles Q. Huang , Fabio C. Tucci
- 申请人地址: US CA San Diego
- 专利权人: Neurocrine Biosciences, Inc.
- 当前专利权人: Neurocrine Biosciences, Inc.
- 当前专利权人地址: US CA San Diego
- 代理机构: Seed IP Law Group PLLC
- 主分类号: C07D239/54
- IPC分类号: C07D239/54 ; A61K31/513
摘要:
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.