发明授权
US07419994B2 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds
失效
4-（取代的环烷基甲基）咪唑-2-硫酮，4-（取代的环烯基甲基）咪唑-2-硫酮，4-（取代的环烷基甲基）咪唑-2-酮和4-（取代的环烯基甲基）咪唑-2-酮和相关化合物
- 专利标题： 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds
- 专利标题（中）： 4-（取代的环烷基甲基）咪唑-2-硫酮，4-（取代的环烯基甲基）咪唑-2-硫酮，4-（取代的环烷基甲基）咪唑-2-酮和4-（取代的环烯基甲基）咪唑-2-酮和相关化合物
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申请号： US11371612申请日： 2006-03-09
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公开(公告)号： US07419994B2公开(公告)日： 2008-09-02
- 发明人: Ken Chow , Todd Heidelbaugh , Daniel Gil , Michael Garst , Larry A. Wheeler , Phong X. Nguyen , Dario G. Gomez
- 申请人： Ken Chow , Todd Heidelbaugh , Daniel Gil , Michael Garst , Larry A. Wheeler , Phong X. Nguyen , Dario G. Gomez
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理机构： Allergan, Inc.
- 代理商 Martin Voet; Brent A. Johnson
- 主分类号： A61K31/4164
- IPC分类号： A61K31/4164 ; C07D233/30
摘要：
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.