发明授权
- 专利标题: 2,6-diaminopyridine derivatives
- 专利标题(中): 2,6-二氨基吡啶衍生物
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申请号: US11165912申请日: 2005-06-24
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公开(公告)号: US07423051B2公开(公告)日: 2008-09-09
- 发明人: David Joseph Bartkovitz , Xin-Jie Chu , Allen John Lovey , Peter Michael Wovkulich
- 申请人: David Joseph Bartkovitz , Xin-Jie Chu , Allen John Lovey , Peter Michael Wovkulich
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni
- 主分类号: A61K31/4545
- IPC分类号: A61K31/4545 ; C07D401/12
摘要:
Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.
公开/授权文献
- US20060014708A1 2,6-Diaminopyridine derivatives 公开/授权日:2006-01-19