发明授权
- 专利标题: Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration
- 专利标题(中): 使用环状吡咯化合物治疗关节软骨或软骨下骨变性
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申请号: US10486912申请日: 2002-08-29
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公开(公告)号: US07425573B2公开(公告)日: 2008-09-16
- 发明人: Jean-Pierre Pelletier , Johanne Martel-Pelletier
- 申请人: Jean-Pierre Pelletier , Johanne Martel-Pelletier
- 申请人地址: DE Blaubeuren CA Montreal
- 专利权人: Merckle GmbH,Ascentia Pharma Inc.
- 当前专利权人: Merckle GmbH,Ascentia Pharma Inc.
- 当前专利权人地址: DE Blaubeuren CA Montreal
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权: CA2356099 20010830
- 国际申请: PCT/EP02/09658 WO 20020829
- 国际公布: WO03/020267 WO 20030313
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/70 ; A61K31/65
摘要:
Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I), wherein the variables have the meanings given in the present description. A preferred compound of formula (I) is formula (II). This treatment ameliorates, diminishes, actively treats, reverses or prevents any injury, damage or loss of articular cartilage or subchondral bone subsequent to said early stage of said degeneration