Invention Grant
- Patent Title: N3 alkylated benzimidazole derivatives as MEK inhibitors
- Patent Title (中): N 3烷基化苯并咪唑衍生物作为MEK抑制剂
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Application No.: US11061336Application Date: 2005-02-18
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Publication No.: US07425637B2Publication Date: 2008-09-16
- Inventor: Eli M. Wallace , Joseph P. Lyssikatos , Allison L. Marlow , T. Brian Hurley
- Applicant: Eli M. Wallace , Joseph P. Lyssikatos , Allison L. Marlow , T. Brian Hurley
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agent John R. Moore
- Main IPC: C07D235/06
- IPC: C07D235/06 ; A61K31/4184
Abstract:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20050143438A1 N3 alkylated benzimidazole derivatives as MEk inhibitors Public/Granted day:2005-06-30
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