A computer enclosure with a locking apparatus includes a front panel (10), a side panel (30), a driving member (52), and a sliding member (55). The side panel has an engaging portion (351). The driving member is pivotable about an axis perpendicular to the front panel, and defines an arcuate portion (531). The sliding member is slidably attached to the front panel. The sliding portion has a stop portion (557) and a driving pin (571). When the driving member is rotated, the arcuate urges the driving pin of the sliding member for driving the sliding member to move, thereby the stop portion engaging with the engaging portion of the side panel and preventing the engaging portion from moving away from the front panel.