发明授权
- 专利标题： Controlled release composition and method of producing the same
- 专利标题（中）： 控制释放组合物及其制备方法
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申请号： US10182731申请日： 2002-06-28
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公开(公告)号： US07429559B2公开(公告)日： 2008-09-30
- 发明人: Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
- 申请人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
- 申请人地址： JP Osaka
- 专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人： Takeda Pharmaceutical Company Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Foley & Lardner LLP
- 优先权： JP2001-199484 20010629; JP2001-340993 20011106
- 国际申请： PCT/JP02/06527 WO 20020628
- 国际公布： WO03/002092 WO 20030109
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
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